a Record control number 000295972800013

a ISSN 1309-0291

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WE 544

b Item number .A5 2011

a Personal name Karakoc-Aydiner, Elif.

h Medium Electronic Document

a Title An Adolescent with Hyperimmunoglobulinemia D and Periodic Fever Syndrome Responding to Simvastatin Treatment.

c Statement of responsibility, etc Safa Baris, Elif Karakoc-Aydiner, Nerin N. Bahceciler, Isil Barlan, Cevdet Ozdemir, Sevgi Keles.

b Name of publisher, distributor, etc Turkish League Against Rheumatism,

c Date of publication, distribution, etc 2011.

a Place of publication, distribution, etc Ankara :

a Summary, etc The hyperimmunoglobulinemia D and periodic fever syndrome is proposed to be caused by a defect in the activity of mevalonate kinase enzyme which is involved in cholesterol and non-sterol isoprenoid biosynthesis. This autosomal recessive inherited auto-inflammatory syndrome is characterized by recurrent fever attacks, abdominal pain, lymphadenopathy, skin lesions and joint involvement. In this article, we present our therapeutic approach with the hypolipidemic agent, simvastatin, in a 12-year-old boy followed up with a diagnosis of hyperimmunoglobulinemia D and periodic fever syndrome. Simvastatin treatment of an adolescent with hyperimmunoglobulinemia D and periodic fever syndrome unresponsive to anti-inflammatory strategies has resulted in a favorable outcome. This treatment is thought to reduce the recurrent fever attacks by reducing the mevalonic acid increase or isopreniod shortage.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Rheumatology.

a Topical term or geographic name as entry element Hyperimmunoglobulinemia D

a Topical term or geographic name as entry element Periodic fever syndrome

g Relationship information 2011,Vol 26 Issue 2, p167-170

t Title Turkish Journal Of Rheumatology

x International Standard Serial Number 13090291

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.5152/tjr.2011.026